Information

The understanding of the male menopause, with respect to reduced serum Estradiol levels, is gaining in importance for the therapy. Until now, little or no attention was paid to the minimal physiological serum Estradiol levels found in men as an explanation for the typical symptomology, which happens to be almost identical to that of women.

A basic prerequisite is, of course, an insight into the physiological spectrum of Estradiol levels found in young and vital men. A differential diagnosis is naturally dependent on the symptom pattern presented by the patient; nevertheless, it can only be confirmed following a measurement of the serum Estradiol in the laboratory. The dosage of Estradiol to be used will be evaluated according to the level of endogenous Estradiol measured. The median dose corresponds to 0.5 mg daily 17ß-Estradiol. Subsequent hormone assays should be taken following determination of the recommended daily initiation dose (4 - 6 weeks). The possible need for dosage titration can be recommended promptly. Even in the presence of a good and stable hormone adjustment, we currently recommend that E₂ should be measured every three months in order to prevent a digression of the patient´s hormone levels from a physiological norm.